Role of apolipoprotein C‐III overproduction in diabetic dyslipidaemia
نویسندگان
چکیده
منابع مشابه
SstI Polymorphism of the Apolipoprotein CIII Gene in Iranian Hyperlipidemic Patients: A Study in Semnan Province
Objective(s) The Sst-I polymorphic site on the 3' untranslated region of the apo CIII gene, has been previously reported to be associated with hypertriglyceridemia. The aim of the present study was to explore the association between Sst-I polymorphism with plasma lipid and lipoprotein levels in hyperlipidemic (HLP) patients from Semnan province, Iran. Materials and Methods Genomic DNA was pr...
متن کاملDiabetic dyslipidaemia in Kuwait.
About 15% of the adult Kuwaiti population has type 2 diabetes and over 50% are hyperlipidaemic by current diagnostic criteria. Not surprisingly, coronary heart disease (CHD) is the leading cause of death in Kuwait. Reports from coronary care units in Kuwait suggest that 40-80% of the CHD patients were diabetic and 50-80% hyperlipidaemic. The pattern worldwide is similar. International guideline...
متن کاملTreatment of diabetic dyslipidaemia.
Lipid evaluation in a diabetic paticnt begins with averaging several measurements of blood sugar, total cholesterol. triacylglycerol and high-density lipoprotein (HDL) cholesterol after a 1 2 h fast. Patients with non-insulin-dependent diabetes may have any one of several of lipid disorders [ 1 I, but typically diabetic dyslipidaemias share the characteristics of high very-low-density lipoprote...
متن کاملLDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients.
OBJECTIVE Triglyceride-rich lipoproteins that contain apolipoprotein CIII (apoCIII) are prominent in diabetic dyslipidemia. We hypothesized that these lipoproteins increase coronary disease risk in diabetic patients beyond that caused by standard lipid risk factors. METHODS AND RESULTS Diabetic patients with previous myocardial infarction were followed for 5 years, and 121 who had a recurrent...
متن کاملTranscriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia.
OBJECTIVE Hypertriglyceridemia and fatty liver are common in patients with type 2 diabetes, but the factors connecting alterations in glucose metabolism with plasma and liver lipid metabolism remain unclear. Apolipoprotein CIII (apoCIII), a regulator of hepatic and plasma triglyceride metabolism, is elevated in type 2 diabetes. In this study, we analyzed whether apoCIII is affected by altered g...
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ژورنال
عنوان ژورنال: Diabetes, Obesity and Metabolism
سال: 2019
ISSN: 1462-8902,1463-1326
DOI: 10.1111/dom.13744